Ontology highlight
ABSTRACT:
SUBMITTER: Dumont M
PROVIDER: S-EPMC3083825 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Dumont Magali M Wille Elizabeth E Calingasan Noel Y NY Tampellini Davide D Williams Charlotte C Gouras Gunnar K GK Liby Karen K Sporn Michael M Nathan Carl C Flint Beal M M Lin Michael T MT
Journal of neurochemistry 20090207 2
Oxidative stress is one of the earliest events in the pathogenesis of Alzheimer's disease (AD) and can markedly exacerbate amyloid pathology. Modulation of antioxidant and anti-inflammatory pathways represents an important approach for AD therapy. Synthetic triterpenoids have been found to facilitate antioxidant response and reduce inflammation in several models. We investigated the effect of the triterpenoid, 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic acid-MethylAmide (CDDO-MA) in Tg19959 mice, w ...[more]