Ontology highlight
ABSTRACT:
SUBMITTER: Frank NY
PROVIDER: S-EPMC3083845 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Frank Natasha Y NY Schatton Tobias T Kim Soo S Zhan Qian Q Wilson Brian J BJ Ma Jie J Saab Karim R KR Osherov Veronika V Widlund Hans R HR Gasser Martin M Waaga-Gasser Ana-Maria AM Kupper Thomas S TS Murphy George F GF Frank Markus H MH
Cancer research 20110106 4
Melanoma growth is driven by malignant melanoma-initiating cells (MMIC) identified by expression of the ATP-binding cassette (ABC) member ABCB5. ABCB5(+) melanoma subpopulations have been shown to overexpress the vasculogenic differentiation markers CD144 (VE-cadherin) and TIE1 and are associated with CD31(-) vasculogenic mimicry (VM), an established biomarker associated with increased patient mortality. Here we identify a critical role for VEGFR-1 signaling in ABCB5(+) MMIC-dependent VM and tum ...[more]