Ontology highlight
ABSTRACT:
SUBMITTER: Pande J
PROVIDER: S-EPMC3083994 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Pande Jyoti J Szewczyk Magdalena M MM Grover Ashok K AK
World journal of biological chemistry 20110301 3
Plasma membrane Ca(2+) pumps (PMCA) play a major role in Ca(2+) homeostasis and signaling by extruding cellular Ca(2+) with high affinity. PMCA isoforms are encoded by four genes which are expressed differentially in various cell types in normal and disease states. Therefore, PMCA isoform selective inhibitors would aid in delineating their role in physiology and pathophysiology. We are testing the hypothesis that extracellular domains of PMCA can be used as allosteric targets to obtain a novel c ...[more]