Protein kinases: evolution of dynamic regulatory proteins.
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ABSTRACT:
SUBMITTER: Taylor SS
PROVIDER: S-EPMC3084033 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Protein kinases: evolution of dynamic regulatory proteins.
Taylor Susan S SS Kornev Alexandr P AP
Trends in biochemical sciences 20101023 2
Eukayotic protein kinases evolved as a family of highly dynamic molecules with strictly organized internal architecture. A single hydrophobic F-helix serves as a central scaffold for assembly of the entire molecule. Two non-consecutive hydrophobic structures termed "spines" anchor all the elements important for catalysis to the F-helix. They make firm, but flexible, connections within the molecule, providing a high level of internal dynamics of the protein kinase. During the course of evolution, ...[more]
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