Ontology highlight
ABSTRACT:
SUBMITTER: Ong CC
PROVIDER: S-EPMC3084065 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Ong Christy C CC Jubb Adrian M AM Haverty Peter M PM Zhou Wei W Tran Victoria V Truong Tom T Turley Helen H O'Brien Tom T Vucic Domagoj D Harris Adrian L AL Belvin Marcia M Friedman Lori S LS Blackwood Elizabeth M EM Koeppen Hartmut H Hoeflich Klaus P KP
Proceedings of the National Academy of Sciences of the United States of America 20110411 17
p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1 in tumorigenesis, PAK1 genomic copy number and expression were determined for a large panel of breast, ...[more]