Ontology highlight
ABSTRACT:
SUBMITTER: Geng Y
PROVIDER: S-EPMC3084141 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Geng Yan Y Dong Yingying Y Yu Mingyan M Zhang Long L Yan Xiaohua X Sun Jingxia J Qiao Long L Geng Huixia H Nakajima Masahiro M Furuichi Tatsuya T Ikegawa Shiro S Gao Xiang X Chen Ye-Guang YG Jiang Dianhua D Ning Wen W
Proceedings of the National Academy of Sciences of the United States of America 20110411 17
Lung morphogenesis is a well orchestrated, tightly regulated process through several molecular pathways, including TGF-β/bone morphogenetic protein (BMP) signaling. Alteration of these signaling pathways leads to lung malformation. We investigated the role of Follistatin-like 1 (Fstl1), a secreted follistatin-module-containing glycoprotein, in lung development. Deletion of Fstl1 in mice led to postnatal lethality as a result of respiratory failure. Analysis of the mutant phenotype showed that Fs ...[more]