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Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population.

ABSTRACT: Several genes have been suggested as dyslexia candidates. Some of these candidate genes have been recently shown to be associated with literacy measures in sample cohorts derived from the general population. Here, we have conducted an association study in a novel sample derived from the Australian population (the Raine cohort) to further investigate the role of dyslexia candidate genes. We analysed markers, previously reported to be associated with dyslexia, located within the MRPL19/C2ORF3, KIAA0319, DCDC2 and DYX1C1 genes in a sample of 520 individuals and tested them for association with reading and spelling measures. Association signals were detected for several single nucleotide polymorphisms (SNPs) within DYX1C1 with both the reading and spelling tests. The high linkage disequilibrium (LD) we observed across the DYX1C1 gene suggests that the association signal might not be refined by further genetic mapping.

SUBMITTER: Paracchini S

PROVIDER: S-EPMC3084500 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population.

Paracchini S S Ang Q W QW Stanley F J FJ Monaco A P AP Pennell C E CE Whitehouse A J O AJ

Genes, brain, and behavior 20101019 2

Several genes have been suggested as dyslexia candidates. Some of these candidate genes have been recently shown to be associated with literacy measures in sample cohorts derived from the general population. Here, we have conducted an association study in a novel sample derived from the Australian population (the Raine cohort) to further investigate the role of dyslexia candidate genes. We analysed markers, previously reported to be associated with dyslexia, located within the MRPL19/C2ORF3, KIA ...[more]

PMID: 20846247

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Project description:BackgroundThe socioecological model proposes a wide array of factors that influence behaviours. There is a need to understand salient correlates of these activity behaviours in a specific population. However, few studies identified socio-demographic, behavioural, physical, and psychological correlates of objectively-assessed physical activity and sedentary time in young adults.MethodsThis was a cross-sectional analysis of participants in the Raine Study (a pregnancy cohort started in 1989). Australian young adults (mean 22.1 years ± SD 0.6) wore Actigraph GT3X+ accelerometers on the hip 24 h/day for seven days to assess moderate-to-vigorous physical activity (MVPA) and sedentary time (n?=?256 women, n?=?219 men). Potential correlates were assessed via clinical assessment and questionnaire and included socio-demographic variables (ethnicity, relationship status, work/study status, education, mothers education), health behaviours (food intake, alcohol consumption, smoking status, sleep quality), and physical and psychological health aspects (anthropometrics, diagnosed disorders, mental health, cognitive performance). Backwards elimination (p?<?0.2 for retention) with mixed model regressions were used and the gender-stratified analyses were adjusted for demographic variables, waking wear time and number of valid days.ResultsIncreased time spent in MVPA was associated with: being single (IRR 1.44 vs in a relationship living together, 95%CI: 1.17, 1.77, p?=?.001) in women; and better sleep quality in men (lower scores better IRR 0.97, 95%CI: 0.93, 1.00). Less time spent sedentary was associated with: lower mother's education (-?32.1 min/day, 95%CI -52.9, 11.3, p?=?0.002 for having mother with no university degree vs at least a baccalaureate degree) and smoking (-?44.3 min/day, 95%CI: - 72.8, -?15.9, p?=?.0002) for women; lower education status (-?32.1 min/day, 95%CI: -59.5, -?4.8, p?=?0.021 for having no university degree vs at least a baccalaureate degree) and lower depression scores in men (-?2.0, 95%CI: - 3.5, -?0.4, p?=?0.014); more alcoholic drinks per week for women (-?1.9 min/day, 95%CI: -3.1, -?0.6, p?=?0.003) and men (-?1.0, 95%CI: -1.8, -?0.3, p?=?0.007).ConclusionsLess desirable correlates were associated with positive levels of activity in young Australian adult women and men. Interventions to increase MVPA and decrease sedentary activity in young adults need to specifically consider the life stage of young adults.

Dataset Information

Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population.

Publications

Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population.

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