Ontology highlight
ABSTRACT:
SUBMITTER: Moncalero VL
PROVIDER: S-EPMC3084716 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Moncalero Vera L VL Costanzo Roxana V RV Perandones Claudia C Radrizzani Martin M
PloS one 20110429 4
PTEN is a critical gene involved in the regulation of many cellular processes. The product of this gene has dual phosphatase activity and is able to dephosphorylate the 5' end of the phosphatidylinositol (3,4,5)-trisphosphate. Within the cellular nucleus, this protein has been associated with regulation of the expression of many genes, although the mechanism of this regulation remains unclear. In this paper, two specific oligonucleotide aptamers were developed and selected, using the SELEX proce ...[more]