Unknown

Dataset Information

0

Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats.

ABSTRACT: One of the major challenges in management of spinal cord injury (SCI) is that the assessment of injury severity is often imprecise. Identification of reliable, easily quantifiable biomarkers that delineate the severity of the initial injury and that have prognostic value for the degree of functional recovery would significantly aid the clinician in the choice of potential treatments. To find such biomarkers we performed quantitative liquid chromatography-mass spectrometry (LC-MS/MS) analyses of cerebrospinal fluid (CSF) collected from rats 24 h after either a moderate or severe SCI. We identified a panel of 42 putative biomarkers of SCI, 10 of which represent potential biomarkers of SCI severity. Three of the candidate biomarkers, Ywhaz, Itih4, and Gpx3 were also validated by Western blot in a biological replicate of the injury. The putative biomarkers identified in this study may potentially be a valuable tool in the assessment of the extent of spinal cord damage.

SUBMITTER: Lubieniecka JM 

PROVIDER: S-EPMC3084780 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

One of the major challenges in management of spinal cord injury (SCI) is that the assessment of injury severity is often imprecise. Identification of reliable, easily quantifiable biomarkers that delineate the severity of the initial injury and that have prognostic value for the degree of functional recovery would significantly aid the clinician in the choice of potential treatments. To find such biomarkers we performed quantitative liquid chromatography-mass spectrometry (LC-MS/MS) analyses of  ...[more]

Similar Datasets

Unknown Parallel Metabolomic Profiling of Cerebrospinal Fluid and Serum for Identifying Biomarkers of Injury Severity after Acute Human Spinal Cord Injury.
| S-EPMC5155264 | biostudies-literature
Unknown Serum and cerebrospinal fluid tau protein level as biomarkers for evaluating acute spinal cord injury severity and motor function outcome.
| S-EPMC6375043 | biostudies-literature
Unknown Treatment of spinal cord injury by transplantation of cells via cerebrospinal fluid.
| S-EPMC5552534 | biostudies-other
Unknown Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury.
| S-EPMC2933055 | biostudies-literature
Unknown Cerebrospinal fluid inflammatory cytokines and chemokines in naturally occurring canine spinal cord injury.
| S-EPMC4161168 | biostudies-literature
Unknown Acute Phase Proteins in Cerebrospinal Fluid from Dogs with Naturally-Occurring Spinal Cord Injury.
| S-EPMC4638197 | biostudies-literature
Unknown Association between Cerebrospinal Fluid and Serum Biomarker Levels and Diagnosis, Injury Severity, and Short-Term Outcomes in Patients with Acute Traumatic Spinal Cord Injury.
| S-EPMC10217493 | biostudies-literature
Unknown Biomarkers for predicting the severity of spinal cord injury by proteomic analysis.
| S-EPMC10753799 | biostudies-literature
Unknown Cerebrospinal fluid and peripheral blood proteomics in Traumatic Spinal Cord Injury: A prospective pilot study.
| S-EPMC9560581 | biostudies-literature
Unknown Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington's Disease.
| S-EPMC5033331 | biostudies-other