Rac1 deletion causes thymic atrophy.
Ontology highlight
ABSTRACT:
SUBMITTER: Hunziker L
PROVIDER: S-EPMC3084817 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Rac1 deletion causes thymic atrophy.
Hunziker Lukas L Benitah Salvador Aznar SA Braun Kristin M KM Jensen Kim K McNulty Katrina K Butler Colin C Potton Elspeth E Nye Emma E Boyd Richard R Laurent Geoff G Glogauer Michael M Wright Nick A NA Watt Fiona M FM Janes Sam M SM
PloS one 20110429 4
The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood. Here we demonstrate that deletion of Rac1 in Keratin 5/Keratin 14 expressing embryonic and adult thymic epithelial cells leads to loss of the thymic epithelial compartment. Rac1 deletion led to an increase in c-Myc expression and a generalized increase in apoptosis associated with a decrease ...[more]
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