Association study of four key folliculogenesis genes in polycystic ovary syndrome.
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ABSTRACT:
SUBMITTER: Sproul K
PROVIDER: S-EPMC3085028 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
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Association study of four key folliculogenesis genes in polycystic ovary syndrome.
Sproul K K Jones M R MR Mathur R R Azziz R R Goodarzi M O MO
BJOG : an international journal of obstetrics and gynaecology 20100312 6
Polycystic ovaries and impaired fertility are the result of abnormal folliculogenesis. Our objective was to determine the role of four candidate folliculogenesis genes in the development of polycystic ovary syndrome (PCOS). Women with and without PCOS (335 cases; 198 controls) were genotyped for single nucleotide polymorphisms in GDF9, BMP15, AMH, and AMHR2. Variants in these genes were not associated with PCOS. Certain GDF9 variants were associated with hirsutism scores and parity in PCOS patie ...[more]
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