Unknown

Dataset Information

0

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk).


ABSTRACT: Continued examination of substituted 6-arylquinazolin-4-amines as Clk4 inhibitors resulted in selective inhibitors of Clk1, Clk4, Dyrk1A and Dyrk1B. Several of the most potent inhibitors were validated as being highly selective within a comprehensive kinome scan.

SUBMITTER: Rosenthal AS 

PROVIDER: S-EPMC3085634 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk).

Rosenthal Andrew S AS   Tanega Cordelle C   Shen Min M   Mott Bryan T BT   Bougie James M JM   Nguyen Dac-Trung DT   Misteli Tom T   Auld Douglas S DS   Maloney David J DJ   Thomas Craig J CJ  

Bioorganic & medicinal chemistry letters 20110304 10


Continued examination of substituted 6-arylquinazolin-4-amines as Clk4 inhibitors resulted in selective inhibitors of Clk1, Clk4, Dyrk1A and Dyrk1B. Several of the most potent inhibitors were validated as being highly selective within a comprehensive kinome scan. ...[more]

Similar Datasets

| S-EPMC3664191 | biostudies-literature
| S-EPMC8199962 | biostudies-literature
| S-EPMC2807730 | biostudies-literature
| S-EPMC10952393 | biostudies-literature
| S-EPMC10104048 | biostudies-literature
| S-EPMC5666424 | biostudies-literature
| S-EPMC5992763 | biostudies-literature
| S-EPMC3556588 | biostudies-literature
| S-EPMC2667211 | biostudies-literature
| S-EPMC9571063 | biostudies-literature