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STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma.

ABSTRACT: Persistent STAT3 signaling contributes to malignant progression in many diverse types of human cancer. STAT3 is constitutively active in activated B-cell (ABC)-like diffuse large B-cell lymphomas (DLBCL), a class of nongerminal center derived DLBCL cells for which existing therapy is weakly effective. In this report, we provide a preclinical proof of concept that STAT3 is an effective molecular target for ABC-like DLBCL therapy. Direct inhibition of STAT3 with short hairpin RNA suppressed the growth of human ABC-like DLBCL in mouse models in a manner associated with apoptosis, repression of STAT3 target genes, and inhibition of a tumor-promoting microenvironment. Together, these results suggest that STAT3 is essential to maintain the pathophysiology of ABC-like DLBCL and therefore that STAT3 inhibition may offer a promising approach in its therapy.

SUBMITTER: Scuto A

PROVIDER: S-EPMC3085657 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma.

Scuto Anna A Kujawski Maciej M Kowolik Claudia C Krymskaya Ludmila L Wang Lin L Weiss Lawrence M LM Digiusto David D Yu Hua H Forman Stephen S Jove Richard R

Cancer research 20110426 9

Persistent STAT3 signaling contributes to malignant progression in many diverse types of human cancer. STAT3 is constitutively active in activated B-cell (ABC)-like diffuse large B-cell lymphomas (DLBCL), a class of nongerminal center derived DLBCL cells for which existing therapy is weakly effective. In this report, we provide a preclinical proof of concept that STAT3 is an effective molecular target for ABC-like DLBCL therapy. Direct inhibition of STAT3 with short hairpin RNA suppressed the gr ...[more]

PMID: 21521803

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