Ontology highlight
ABSTRACT:
SUBMITTER: Lee Y
PROVIDER: S-EPMC3085955 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Lee Younjoo Y Choi Jun Yong JY Fu Hong H Harvey Colin C Ravindran Sandeep S Roush William R WR Boothroyd John C JC Khosla Chaitan C
Journal of medicinal chemistry 20110323 8
Macrolide antibacterial agents inhibit parasite proliferation by targeting the apicoplast ribosome. Motivated by the long-term goal of identifying antiparasitic macrolides that lack antibacterial activity, we have systematically analyzed the structure-activity relationships among erythromycin analogues and have also investigated the mechanism of action of selected compounds. Two lead compounds, N-benzylazithromycin (11) and N-phenylpropylazithromycin (30), were identified with significantly high ...[more]