Small voltage changes at nerve terminals travel up axons to affect action potential initiation.
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ABSTRACT:
SUBMITTER: Paradiso K
PROVIDER: S-EPMC3086371 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Small voltage changes at nerve terminals travel up axons to affect action potential initiation.
Paradiso Kenneth K Wu Ling-Gang LG
Nature neuroscience 20090406 5
Nerve terminals are generally considered to be the destination points for electrical signals, which propagate unidirectionally from the soma to nerve terminals. We found that small hyperpolarizations or depolarizations ( approximately 10 mV) generated under physiological conditions in rat nerve terminals backpropagated up the axon ( approximately 400-800 microm) and changed the threshold for initiating action potentials and thus firing patterns. These results suggest a mechanism for information ...[more]
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