Unknown

Dataset Information

0

Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010.


ABSTRACT: Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (dual) resistance from 5 countries belonging to 4 distinct genotypes. Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored.

SUBMITTER: Sheu TG 

PROVIDER: S-EPMC3086447 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010.

Sheu Tiffany G TG   Fry Alicia M AM   Garten Rebecca J RJ   Deyde Varough M VM   Shwe Thein T   Bullion Lesley L   Peebles Patrick J PJ   Li Yan Y   Klimov Alexander I AI   Gubareva Larisa V LV  

The Journal of infectious diseases 20110101 1


Two distinct genetic clades of seasonal influenza A(H1N1) viruses have cocirculated in the recent seasons: clade 2B oseltamivir-resistant and adamantane-susceptible viruses, and clade 2C viruses that are resistant to adamantanes and susceptible to oseltamivir. We tested seasonal influenza A(H1N1) viruses collected in 2008-2010 from the United States and globally for resistance to antivirals approved by the Food and Drug Administration. We report 28 viruses with both adamantane and oseltamivir (d  ...[more]

Similar Datasets

| S-EPMC3147846 | biostudies-literature
| S-EPMC2630761 | biostudies-literature
| S-EPMC5781210 | biostudies-literature
| S-EPMC3416348 | biostudies-literature
| S-EPMC2727327 | biostudies-literature
| S-EPMC2657637 | biostudies-literature
| S-EPMC3599939 | biostudies-literature
| S-EPMC3086245 | biostudies-literature
| S-EPMC2928817 | biostudies-literature
| S-EPMC3069057 | biostudies-literature