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Preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold.

ABSTRACT: This paper reports the preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold. The reported synthetic route uses nortropane-8-carbonyl chlorides as key intermediates that, when treated with a slight excess of amine, give the corresponding ureas in high yield (129 examples).

SUBMITTER: Agarkov A

PROVIDER: S-EPMC3086471 | biostudies-literature | 2008 Sep-Oct

REPOSITORIES: biostudies-literature

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Preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold.

Agarkov Anton A Gilbertson Scott R SR

Journal of combinatorial chemistry 20080709 5

This paper reports the preparation of a library of unsymmetrical ureas based on 8-azabicyclo[3.2.1]octane scaffold. The reported synthetic route uses nortropane-8-carbonyl chlorides as key intermediates that, when treated with a slight excess of amine, give the corresponding ureas in high yield (129 examples). ...[more]

PMID: 18611055

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