Ontology highlight
ABSTRACT:
SUBMITTER: Shepherd BE
PROVIDER: S-EPMC3086582 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Shepherd Bryan E BE Jenkins Cathy A CA Rebeiro Peter F PF Stinnette Samuel E SE Bebawy Sally S SS McGowan Catherine C CC Hulgan Todd T Sterling Timothy R TR
Epidemiology (Cambridge, Mass.) 20100901 5
<h4>Background</h4>Optimal timing of antiretroviral therapy in HIV-infected persons is unclear, although 2 recent large observational studies have improved our understanding of the best CD4 threshold for initiation. These studies compared the effect of starting HAART on mortality and mortality/AIDS between strata defined using broad ranges of CD4 counts. We sought to expand this understanding using a novel statistical approach proposed by Robins et al.<h4>Methods</h4>Using observational data fro ...[more]