Ontology highlight
ABSTRACT:
SUBMITTER: Mastarone DJ
PROVIDER: S-EPMC3086647 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Mastarone Daniel J DJ Harrison Victoria S R VS Eckermann Amanda L AL Parigi Giacomo G Luchinat Claudio C Meade Thomas J TJ
Journal of the American Chemical Society 20110317 14
We have developed a modular architecture for preparing high-relaxivity multiplexed probes utilizing click chemistry. Our system incorporates azide bearing Gd(III) chelates and a trialkyne scaffold with a functional group for subsequent modification. In optimizing the relaxivity of this new complex, we undertook a study of the linker length between a chelate and the scaffold to determine its effect on relaxivity. The results show a strong dependence on flexibility between the individual chelates ...[more]