Ontology highlight
ABSTRACT:
SUBMITTER: Wilson RC
PROVIDER: S-EPMC3086721 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Wilson Randall C RC Edmondson Stephen P SP Flatt Justin W JW Flatt Justin W JW Helms Kimberli K Twigg Pamela D PD
Biochemical and biophysical research communications 20110131 4
E2-25K is an ubiquitin-conjugating enzyme with the ability to synthesize Lys48-linked polyubiquitin chains. E2-25K and its homologs represent the only known E2 enzymes which contain a C-terminal ubiquitin-associated (UBA) domain as well as the conserved catalytic ubiquitin-conjugating (UBC) domain. As an additional non-covalent binding surface for ubiquitin, the UBA domain must provide some functional specialization. We mapped the protein-protein interface involved in the E2-25K UBA/ubiquitin co ...[more]