Ontology highlight
ABSTRACT:
SUBMITTER: Hawke RL
PROVIDER: S-EPMC3086763 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Hawke Roy L RL Schrieber Sarah J SJ Soule Tedi A TA Wen Zhiming Z Smith Philip C PC Reddy K Rajender KR Wahed Abdus S AS Belle Steven H SH Afdhal Nezam H NH Navarro Victor J VJ Berman Josh J Liu Qi-Ying QY Doo Edward E Fried Michael W MW
Journal of clinical pharmacology 20091019 4
Silymarin, derived from the milk thistle plant Silybum marianum, is widely used for self-treatment of liver diseases, including hepatitis C virus (HCV), and its antiviral activity has been demonstrated in vitro and in HCV patients administered an intravenous formulation of the major silymarin flavonolignans, silybin A and silybin B. The safety and dose-exposure relationships of higher than customary oral doses of silymarin and its acute effects on serum HCV RNA were evaluated in noncirrhotic HCV ...[more]