Ontology highlight
ABSTRACT:
SUBMITTER: Harbour JW
PROVIDER: S-EPMC3087380 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Harbour J William JW Onken Michael D MD Roberson Elisha D O ED Duan Shenghui S Cao Li L Worley Lori A LA Council M Laurin ML Matatall Katie A KA Helms Cynthia C Bowcock Anne M AM
Science (New York, N.Y.) 20101104 6009
Metastasis is a defining feature of malignant tumors and is the most common cause of cancer-related death, yet the genetics of metastasis are poorly understood. We used exome capture coupled with massively parallel sequencing to search for metastasis-related mutations in highly metastatic uveal melanomas of the eye. Inactivating somatic mutations were identified in the gene encoding BRCA1-associated protein 1 (BAP1) on chromosome 3p21.1 in 26 of 31 (84%) metastasizing tumors, including 15 mutati ...[more]