Dataset Information

Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis.

ABSTRACT:

Objectives

The goal of this study was to determine if memory would be improved by donepezil as compared to placebo in a multicenter, double-blind, randomized clinical trial (RCT).

Methods

Donepezil 10 mg daily was compared to placebo to treat memory impairment. Eligibility criteria included the following: age 18-59 years, clinically definite multiple sclerosis (MS), and performance ? ½ SD below published norms on the Rey Auditory Verbal Learning Test (RAVLT). Neuropsychological assessments were performed at baseline and 24 weeks. Primary outcomes were change on the Selective Reminding Test (SRT) of verbal memory and the participant's impression of memory change. Secondary outcomes included changes on other neuropsychological tests and the evaluating clinician's impression of memory change.

Results

A total of 120 participants were enrolled and randomized to either donepezil or placebo. No significant treatment effects were found between groups on either primary outcome of memory or any secondary cognitive outcomes. A trend was noted for the clinician's impression of memory change in favor of donepezil (37.7%) vs placebo (23.7%) (p = 0.097). No serious or unanticipated adverse events attributed to study medication developed.

Conclusions

Donepezil did not improve memory as compared to placebo on either of the primary outcomes in this study.

Classification of evidence

This study provides Class I evidence which does not support the hypothesis that 10 mg of donepezil daily for 24 weeks is superior to placebo in improving cognition as measured by the SRT in people with MS whose baseline RAVLT score was 0.5 SD or more below average.

SUBMITTER: Krupp LB

PROVIDER: S-EPMC3087469 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis.

Krupp L B LB Christodoulou C C Melville P P Scherl W F WF Pai L-Y LY Muenz L R LR He D D Benedict R H B RH Goodman A A Rizvi S S Schwid S R SR Weinstock-Guttman B B Westervelt H J HJ Wishart H H

Neurology 20110401 17

<h4>Objectives</h4>The goal of this study was to determine if memory would be improved by donepezil as compared to placebo in a multicenter, double-blind, randomized clinical trial (RCT).<h4>Methods</h4>Donepezil 10 mg daily was compared to placebo to treat memory impairment. Eligibility criteria included the following: age 18-59 years, clinically definite multiple sclerosis (MS), and performance ≤ ½ SD below published norms on the Rey Auditory Verbal Learning Test (RAVLT). Neuropsychological as ...[more]

PMID: 21519001

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Dataset Information

Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis.

Objectives

Methods

Results

Conclusions

Classification of evidence

Publications

Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis.

Similar Datasets

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