Ontology highlight
ABSTRACT:
SUBMITTER: Kohler A
PROVIDER: S-EPMC3087483 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Köhler Anja A De Filippo Katia K Hasenberg Mike M van den Brandt Cindy C Nye Emma E Hosking Martin P MP Lane Thomas E TE Männ Linda L Ransohoff Richard M RM Hauser Anja E AE Winter Oliver O Schraven Burkhart B Geiger Hartmut H Hogg Nancy N Gunzer Matthias M
Blood 20110111 16
Emergency mobilization of neutrophil granulocytes (neutrophils) from the bone marrow (BM) is a key event of early cellular immunity. The hematopoietic cytokine granulocyte-colony stimulating factor (G-CSF) stimulates this process, but it is unknown how individual neutrophils respond in situ. We show by intravital 2-photon microscopy that a systemic dose of human clinical-grade G-CSF rapidly induces the motility and entry of neutrophils into blood vessels within the tibial BM of mice. Simultaneou ...[more]