Ontology highlight
ABSTRACT:
SUBMITTER: Wang GJ
PROVIDER: S-EPMC3087617 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Wang George J GJ Kang Lijun L Kim Julie E JE Maro Géraldine S GS Xu X Z Shawn XZ Shen Kang K
Nature neuroscience 20101031 12
AMPA receptors mediate most of the fast postsynaptic response at glutamatergic synapses. The abundance of AMPA receptors in neurons and at postsynaptic membranes is tightly regulated. It has been suggested that changes in synaptic AMPA receptor levels are an important regulatory event in synaptic plasticity and learning and memory. Although the local, synapse-specific regulation of AMPA receptors has been intensely studied, global, cell-wide control is less well understood. Using a forward genet ...[more]