Ontology highlight
ABSTRACT:
SUBMITTER: Tubbs JL
PROVIDER: S-EPMC3088651 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Tubbs Julie L JL Tainer John A JA
Cellular and molecular life sciences : CMLS 20100526 22
Alkyltransferase-like proteins (ATLs) play a role in the protection of cells from the biological effects of DNA alkylation damage. Although ATLs share functional motifs with the DNA repair protein and cancer chemotherapy target O⁶-alkylguanine-DNA alkyltransferase, they lack the reactive cysteine residue required for alkyltransferase activity, so its mechanism for cell protection was previously unknown. Here we review recent advances in unraveling the enigmatic cellular protection provided by AT ...[more]