Ontology highlight
ABSTRACT:
SUBMITTER: Ishizuka K
PROVIDER: S-EPMC3088774 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Nature 20110406 7345
Regulatory mechanisms governing the sequence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly understood. Here we report that phosphorylation of DISC1, a major susceptibility factor for several mental disorders, acts as a molecular switch from maintaining proliferation of mitotic progenitor cells to activating migration of postmitotic neurons in mice. Unphosphorylated DISC1 regulates canonical Wnt signalling via an interaction with GSK3β, whereas specific ...[more]