Drug-induced cholestasis.
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ABSTRACT:
SUBMITTER: Padda MS
PROVIDER: S-EPMC3089004 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Drug-induced cholestasis.
Padda Manmeet S MS Sanchez Mayra M Akhtar Abbasi J AJ Boyer James L JL
Hepatology (Baltimore, Md.) 20110401 4
Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management. ...[more]
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