Ontology highlight
ABSTRACT:
SUBMITTER: Schulze K
PROVIDER: S-EPMC308920 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Schulze Kai K Medina Eva E Chhatwal Gursharan S GS Guzmán Carlos A CA
Infection and immunity 20031201 12
The fibronectin-binding repeats of the SfbI protein of Streptococcus pyogenes constitute the minimal domain able to confer protection against lethal infection. We investigated the presence of B- and T-cell epitopes within this region in congenic mice. One linear B-cell epitope was recognized by BALB/b and BALB/k mice, whereas two epitopes were found in BALB/c animals. A unique T-cell epitope was recognized by all three mouse strains. All identified epitopes clustered in a 30-amino-acid fragment. ...[more]