Ontology highlight
ABSTRACT:
SUBMITTER: Vermeulen J
PROVIDER: S-EPMC3089491 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Vermeulen Joëlle J De Preter Katleen K Lefever Steve S Nuytens Justine J De Vloed Fanny F Derveaux Stefaan S Hellemans Jan J Speleman Frank F Vandesompele Jo J
Nucleic acids research 20110211 9
Compromised RNA quality is suggested to lead to unreliable results in gene expression studies. Therefore, assessment of RNA integrity and purity is deemed essential prior to including samples in the analytical pipeline. This may be of particular importance when diagnostic, prognostic or therapeutic conclusions depend on such analyses. In this study, the comparative value of six RNA quality parameters was determined using a large panel of 740 primary tumour samples for which real-time quantitativ ...[more]