Ontology highlight
ABSTRACT:
SUBMITTER: Figueiredo JC
PROVIDER: S-EPMC3089660 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Figueiredo Jane C JC Lewinger Juan Pablo JP Song Chi C Campbell Peter T PT Conti David V DV Edlund Christopher K CK Duggan Dave J DJ Rangrej Jagadish J Lemire Mathieu M Hudson Thomas T Zanke Brent B Cotterchio Michelle M Gallinger Steven S Jenkins Mark M Hopper John J Haile Robert R Newcomb Polly P Potter John J Baron John A JA Le Marchand Loic L Casey Graham G
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110225 5
<h4>Background</h4>Genome-wide association studies (GWAS) have led to the identification of a number of common susceptibility loci for colorectal cancer (CRC); however, none of these GWAS have considered gene-environment (G × E) interactions. Therefore, it is unclear whether current hits are modified by environmental exposures or whether there are additional hits whose effects are dependent on environmental exposures.<h4>Methods</h4>We conducted a systematic search for G × E interactions using g ...[more]