Structural basis of the 9-fold symmetry of centrioles.
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ABSTRACT:
SUBMITTER: Kitagawa D
PROVIDER: S-EPMC3089914 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Structural basis of the 9-fold symmetry of centrioles.
Kitagawa Daiju D Vakonakis Ioannis I Olieric Natacha N Hilbert Manuel M Keller Debora D Olieric Vincent V Bortfeld Miriam M Erat Michèle C MC Flückiger Isabelle I Gönczy Pierre P Steinmetz Michel O MO
Cell 20110201 3
The centriole, and the related basal body, is an ancient organelle characterized by a universal 9-fold radial symmetry and is critical for generating cilia, flagella, and centrosomes. The mechanisms directing centriole formation are incompletely understood and represent a fundamental open question in biology. Here, we demonstrate that the centriolar protein SAS-6 forms rod-shaped homodimers that interact through their N-terminal domains to form oligomers. We establish that such oligomerization i ...[more]
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