Ontology highlight
ABSTRACT:
SUBMITTER: Peca J
PROVIDER: S-EPMC3090611 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Peça João J Feliciano Cátia C Ting Jonathan T JT Wang Wenting W Wells Michael F MF Venkatraman Talaignair N TN Lascola Christopher D CD Fu Zhanyan Z Feng Guoping G
Nature 20110320 7344
Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of neurobehavioural deficits characterized by widespread abnormalities in social interactions, deficits in communication as well as restricted interests and repetitive behaviours. The neurological basis and circuitry mechanisms underlying these abnormal behaviours are poorly understood. SHANK3 is a postsynaptic protein, whose disruption at the genetic level is thought to be responsible for the development of 22q13 d ...[more]