Ontology highlight
ABSTRACT:
SUBMITTER: Hemsworth GR
PROVIDER: S-EPMC3091252 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Hemsworth Glyn R GR Moroz Olga V OV Fogg Mark J MJ Scott Benjamin B Bosch-Navarrete Cristina C González-Pacanowska Dolores D Wilson Keith S KS
The Journal of biological chemistry 20110315 18
Members of the Leishmania genus are the causative agents of the life-threatening disease leishmaniasis. New drugs are being sought due to increasing resistance and adverse side effects with current treatments. The knowledge that dUTPase is an essential enzyme and that the all α-helical dimeric kinetoplastid dUTPases have completely different structures compared with the trimeric β-sheet type dUTPase possessed by most organisms, including humans, make the dimeric enzymes attractive drug targets. ...[more]