Ontology highlight
ABSTRACT:
SUBMITTER: Brooks CL
PROVIDER: S-EPMC3091419 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Brooks Cory L CL Müller-Loennies Sven S Borisova Svetlana N SN Brade Lore L Kosma Paul P Hirama Tomoko T Mackenzie C Roger CR Brade Helmut H Evans Stephen V SV
Biochemistry 20100101 3
The structures of antigen-binding fragments from two related monoclonal antibodies have been determined to high resolution in the presence of several carbohydrate antigens raised against chlamydial lipopolysaccharide. With the exception of CDR H3, antibodies S54-10 and S73-2 are both derived from the same set of germline gene segments as the previously reported structures S25-2 and S45-18. Despite this similarity, the antibodies differ in specificity and the mechanism by which they recognize the ...[more]