No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight.
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ABSTRACT:
SUBMITTER: Smith DL
PROVIDER: S-EPMC3091992 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
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No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight.
Smith D L DL Robertson H T HT Desmond R A RA Nagy T R TR Allison D B DB
International journal of obesity (2005) 20101116 5
<h4>Objective</h4>The health and longevity effects of body weight reduction resulting from exercise and caloric restriction in rodents are well known, but less is known about whether similar effects occur with weight reduction from the use of a pharmaceutical agent such as sibutramine, a serotonin-norepinephrine reuptake inhibitor.<h4>Results and conclusion</h4>Using data from a 2-year toxicology study of sibutramine in Sprague-Dawley CD rats and CD-1 mice, despite a dose-dependent reduction in ...[more]
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