Ontology highlight
ABSTRACT:
SUBMITTER: Fraser JS
PROVIDER: S-EPMC3092063 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Fraser James S JS Jackson Colin J CJ
Cellular and molecular life sciences : CMLS 20101229 11
This review focuses on conceptual and methodological advances in our understanding and characterization of the conformational heterogeneity of proteins. Focusing on X-ray crystallography, we describe how polysterism, the interconversion of pre-existing conformational substates, has traditionally been analyzed by comparing independent crystal structures or multiple chains within a single crystal asymmetric unit. In contrast, recent studies have focused on mining electron density maps to reveal pr ...[more]