Ontology highlight
ABSTRACT:
SUBMITTER: Kim T
PROVIDER: S-EPMC3092351 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Kim Taewan T Veronese Angelo A Pichiorri Flavia F Lee Tae Jin TJ Jeon Young-Jun YJ Volinia Stefano S Pineau Pascal P Marchio Agnès A Palatini Jeff J Suh Sung-Suk SS Alder Hansjuerg H Liu Chang-Gong CG Dejean Anne A Croce Carlo M CM
The Journal of experimental medicine 20110425 5
p53 suppresses tumor progression and metastasis. Epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis. The transcription factors ZEB1 and ZEB2 promote EMT. Here, we show that p53 suppresses EMT by repressing expression of ZEB1 and ZEB2. By profiling 92 primary hepatocellular carcinomas (HCCs) and 9 HCC cell lines, we found that p53 up-regulates microRNAs (miRNAs), including miR-200 and miR-192 family members. The miR-200 family members transactivated by p5 ...[more]