Unknown

Dataset Information

0

C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity.


ABSTRACT: A highly regio- and stereo-selective asymmetric synthesis of various C5'-alkyl side chains of rhamnosyl- and amicetosyl-digitoxigenin analogs has been established via palladium-catalyzed glycosylation with post-glycosylated dihydroxylation or diimide reduction. The C5'-methyl group in both α-l-rhamnose and α-l-amicetose digitoxin analogs displayed a steric directed apoptosis induction and tumor growth inhibition against non-small cell human lung cancer cells (NCI-H460). The anti-tumor activity is significantly reduced when the steric hindrance is increased at C5'-stereocenter.

SUBMITTER: Wang HY 

PROVIDER: S-EPMC3092485 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5413833 | biostudies-literature
| S-EPMC5713421 | biostudies-other
| S-EPMC1317918 | biostudies-literature
| S-EPMC3108330 | biostudies-literature
| S-EPMC6933791 | biostudies-literature
| S-EPMC5768141 | biostudies-literature
| S-EPMC2980783 | biostudies-literature
| S-EPMC4265826 | biostudies-other
| S-EPMC6015005 | biostudies-literature
| S-EPMC7925339 | biostudies-literature