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The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese.

ABSTRACT: AIMS: The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether the SLC2A9 gene variations are associated with type 2 DM in Han Chinese. METHODS: Three common SNPs of the SLC2A9, rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan. RESULTS: The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM (P = .002). Per-copy increase in the minor C-allele results in 0.13?mmol/L (P = .037) and 10.03??mol/L (P = .016) decrease in serum glucose and UA, respectively. CONCLUSIONS: The SNP rs1014290 within the SLC2A9 gene is associated with type 2 DM in Han Chinese.

SUBMITTER: Liu WC

PROVIDER: S-EPMC3092507 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese.

Liu Wan-Chun WC Hung Chi-Chih CC Chen Szu-Chia SC Lin Ming-Yen MY Chen Ling-I LI Hwang Daw-Yang DY Chang Jer-Ming JM Tsai Jer-Chia JC Chen Hung-Chun HC Hwang Shang-Jyh SJ

Experimental diabetes research 20110414

<h4>Aims</h4>The SLC2A9 gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) of SLC2A9 accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether the SLC2A9 gene variations are associated with type 2 DM in Han Chinese.<h4>Methods</h4>Three common SNP ...[more]

PMID: 21584282

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Project description:BACKGROUND:Type 2 diabetes mellitus (T2DM) is a metabolic disorder which accounts for high morbidity and mortality due to complications like renal failure, amputations, cardiovascular disease, and cerebrovascular events. METHODS:We collected medical reports, lifestyle details, and blood samples of individuals and used the polymerase chain reaction-ligase detection reaction method to genotype the SNPs, and a visit was conducted in August 2016 to obtain the incidence of Type 2 diabetes in the 2113 eligible people. To explore which genes and environmental factors are associated with type 2 diabetes mellitus in a Chinese Han population, we used elastic net to build a model, which is to explain which variables are strongly associated with T2DM, rather than predict the occurrence of T2DM. RESULT:The genotype of the additive of rs964184, together with the history of hypertension, regular intake of meat and waist circumference, increased the risk of T2DM (adjusted OR?=?2.38, p?=?0.042; adjusted OR?=?3.31, p?<?0.001; adjusted OR?=?1.05, p?<?0.001). The TT genotype of the additive and recessive models of rs12654264, the CC genotype of the additive and dominant models of rs2065412, the TT genotype of the additive and dominant models of rs4149336, together with the degree of education, regular exercise, reduced the risk of T2DM (adjusted OR?=?0.46, p?=?0.017; adjusted OR?=?0.53, p?=?0.021; adjusted OR?=?0.59, p?=?0.021; adjusted OR?=?0.57, p?=?0.01; adjusted OR?=?0.59, p?=?0.021; adjusted OR?=?0.57, p?=?0.01; adjusted OR?=?0.50, p?=?0.007; adjusted OR?=?0.80, p?=?0.032) . CONCLUSION:Eventually we identified a set of SNPs and environmental factors: rs5805 in the SLC12A3, rs12654264 in the HMGCR, rs2065412 and rs414936 in the ABCA1, rs96418 in the ZPR1 gene, waistline, degree of education, exercise frequency, hypertension, and the intake of meat. Although there was no interaction between these variables, people with two risk factors had a higher risk of T2DM than those only having one factor. These results provide the theoretical basis for gene and other risk factors screening to prevent T2DM.

Dataset Information

The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese.

Publications

The rs1014290 polymorphism of the SLC2A9 gene is associated with type 2 diabetes mellitus in Han Chinese.

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