Ontology highlight
ABSTRACT:
SUBMITTER: Moglich A
PROVIDER: S-EPMC3092527 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20091001 10
Per-ARNT-Sim (PAS) domains serve as versatile sensor and interaction modules in signal transduction proteins. PAS sensors detect chemical and physical stimuli and regulate the activity of functionally diverse effector domains. In contrast to this chemical, physical, and functional diversity, the structure of the core of PAS domains is broadly conserved and comprises a five-stranded antiparallel beta sheet and several alpha helices. Signals originate within the conserved core and generate structu ...[more]