Ontology highlight
ABSTRACT:
SUBMITTER: Grueter BA
PROVIDER: S-EPMC3092590 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Grueter Brad A BA Brasnjo Gabor G Malenka Robert C RC
Nature neuroscience 20101114 12
Synaptic modifications in the nucleus accumbens (NAc) are important for adaptive and pathological reward-dependent learning. Medium spiny neurons (MSNs), the major cell type in the NAc, participate in two parallel circuits that subserve distinct behavioral functions, yet little is known about differences in their electrophysiological and synaptic properties. Using bacterial artificial chromosome transgenic mice, we found that synaptic activation of group I metabotropic glutamate receptors in NAc ...[more]