Ontology highlight
ABSTRACT:
SUBMITTER: Chen G
PROVIDER: S-EPMC3092643 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Chen Guozhou G Swem Lee R LR Swem Danielle L DL Stauff Devin L DL O'Loughlin Colleen T CT Jeffrey Philip D PD Bassler Bonnie L BL Hughson Frederick M FM
Molecular cell 20110401 2
Quorum-sensing bacteria communicate via small molecules called autoinducers to coordinate collective behaviors. Because quorum sensing controls virulence factor expression in many clinically relevant pathogens, membrane-permeable quorum sensing antagonists that prevent population-wide expression of virulence genes offer a potential route to novel antibacterial therapeutics. Here, we report a strategy for inhibiting quorum-sensing receptors of the widespread LuxR family. Structure-function studie ...[more]