Ontology highlight
ABSTRACT:
SUBMITTER: Avilan L
PROVIDER: S-EPMC3092696 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Avilán Luisana L Gualdrón-López Melisa M Quiñones Wilfredo W González-González Limari L Hannaert Véronique V Michels Paul A M PA Concepción Juan-Luis JL
Enzyme research 20110407
Glycolysis and glyconeogenesis play crucial roles in the ATP supply and synthesis of glycoconjugates, important for the viability and virulence, respectively, of the human-pathogenic stages of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp. These pathways are, therefore, candidate targets for antiparasite drugs. The glycolytic/gluconeogenic enzyme enolase is generally highly conserved, with similar overall fold and identical catalytic residues in all organisms. Nonetheless, potentiall ...[more]