Hindered dissolution of fibrin formed under mechanical stress.

ABSTRACT:

Background

Recent data indicate that stretching forces cause a dramatic decrease in clot volume accompanied by gross conformational changes of fibrin structure.

Objective

The present study attempts to characterize the lytic susceptibility of fibrin exposed to mechanical stress as a model for fibrin structures observed in vivo.

Methods and results

The relevance of stretched fibrin models was substantiated by scanning electron microscopic (SEM) evaluation of human thrombi removed during surgery, where surface fibrin fibers were observed to be oriented in the direction of shear forces, whereas interior fibers formed a random spatial meshwork. These structural variations were modeled in vitro with fibrin exposed to adjustable mechanical stress. After two- and three-fold l

SUBMITTER: Varju I 

PROVIDER: S-EPMC3093023 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature