Ambient oxygen promotes tumorigenesis.
Ontology highlight
ABSTRACT:
SUBMITTER: Sung HJ
PROVIDER: S-EPMC3093396 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
Ambient oxygen promotes tumorigenesis.
Sung Ho Joong HJ Ma Wenzhe W Starost Matthew F MF Lago Cory U CU Lim Philip K PK Sack Michael N MN Kang Ju-Gyeong JG Wang Ping-yuan PY Hwang Paul M PM
PloS one 20110512 5
Oxygen serves as an essential factor for oxidative stress, and it has been shown to be a mutagen in bacteria. While it is well established that ambient oxygen can also cause genomic instability in cultured mammalian cells, its effect on de novo tumorigenesis at the organismal level is unclear. Herein, by decreasing ambient oxygen exposure, we report a ∼50% increase in the median tumor-free survival time of p53-/- mice. In the thymus, reducing oxygen exposure decreased the levels of oxidative DNA ...[more]
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