Ontology highlight
ABSTRACT:
SUBMITTER: Perez J
PROVIDER: S-EPMC3094139 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Perez Jacqueline J Brandon J Anthony JA Cohen Donald A DA Jennings C Darrell CD Kaplan Alan M AM Bryson J Scott JS
American journal of physiology. Gastrointestinal and liver physiology 20110203 5
Syngeneic graft vs. host disease (SGVHD) was first described as a graft vs. host disease-like syndrome that developed in rats following syngeneic bone marrow transplantation (BMT) and cyclosporin A (CsA) treatment. SGVHD can be induced by reconstitution of lethally irradiated mice with syngeneic bone marrow cells followed by 21 days of treatment with the immunosuppressive agent CsA. Clinical symptoms of the disease appear 2-3 wk following cessation of CsA therapy, and disease-associated inflamma ...[more]