Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC3094727 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Lee Seunghoon S Kim Kyongmin K Zhou Z Jimmy ZJ
Neuron 20101201 6
Starburst amacrine cells (SACs) process complex visual signals in the retina using both acetylcholine (ACh) and gamma-aminobutyric acid (GABA), but the synaptic organization and function of ACh-GABA corelease remain unclear. Here, we show that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergic synapses onto DSGCs only from the null direction. ACh and GABA were released differentially in a Ca(2+) level-specific manner, sugg ...[more]