Ontology highlight
ABSTRACT:
SUBMITTER: Polymenidou M
PROVIDER: S-EPMC3094729 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Polymenidou Magdalini M Lagier-Tourenne Clotilde C Hutt Kasey R KR Huelga Stephanie C SC Moran Jacqueline J Liang Tiffany Y TY Ling Shuo-Chien SC Sun Eveline E Wancewicz Edward E Mazur Curt C Kordasiewicz Holly H Sedaghat Yalda Y Donohue John Paul JP Shiue Lily L Bennett C Frank CF Yeo Gene W GW Cleveland Don W DW
Nature neuroscience 20110227 4
We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding protein that, when mutated, causes amyotrophic lateral sclerosis. Massively parallel sequencing and splicing-sensitive junction arrays revealed that levels of 601 mRNAs were changed (including Fus (Tls), progranulin and other transcripts encoding neurodegenerative disease-associated proteins) and 965 altered splicing ev ...[more]