Methods for predicting cortical UP and DOWN states from the phase of deep layer local field potentials.

ABSTRACT: During anesthesia, slow-wave sleep and quiet wakefulness, neuronal membrane potentials collectively switch between de- and hyperpolarized levels, the cortical UP and DOWN states. Previous studies have shown that these cortical UP/DOWN states affect the excitability of individual neurons in response to sensory stimuli, indicating that a significant amount of the trial-to-trial variability in neuronal responses can be attributed to ongoing fluctuations in network activity. However, as intracellular recordings are frequently not available, it is important to be able to estimate their occurrence purely from extracellular data. Here, we combine in vivo whole cell recordings from single neurons with multi-site extracellular microelectrode recordings, to quantify the performance of various approa

SUBMITTER: Saleem AB 

PROVIDER: S-EPMC3094772 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature